Previous Scholars' Accomplishments

2023-2024

Emily Boyt '23

Research Project: Development of Multivalent Bioconjugates Employing Unnatural Amino Acids.

Yigit Simsek '23

Research Project: The Role of Lysine Deacetylases (KDACs) in the Thyroid Hormone Receptor Nucleocytoplasmic Trafficking Pathway.

2022-2023

Quinton Reed '22

Research Project: Validating the Interaction Between MK-STYX and ACTA1 in HEK 293 cells.

Alana Thomas '22

Research Project: Advancing the Fieldability and Safety of Synthetic Circuits.

2021-2022

Naya Burrow '21

Research Project: Preparation of Multivalent Bioconjugates Employing Unnatural Amino Acids.

2020-2021

Henry Cardwell '20

Research Project: Determination of Experimental and Computational Gas Phase Proton Affinities of Proline Containing Dipeptides.

2019-2020

Nicole Carrillo-Vallejo '19

Research Project: Synthesizing Pyridine Derivatives Through Cycloaddition/Cycloreversion Processes.

Ziyan Chen '19

Research Project: The Role of Flo11 in Homotypic Binding and Self-Recognition in S. Cerevisiae.

2018-2019

Lauren Mazur '18

Research Project: Solid-Supported Glaser-Hay Coupling of Propargylic and Homorpropargylic Alcohols: Preparation and Biological Analyses.

Grace Solini '18

Reseach Project: Promoter Architecture and Transcriptional Noise in Synthetic Signaling Circuits.

2017-2018

Christopher Travis '17

Research Project: Using Unnatural Amino Acids and Profluorophores to Diagnose and Treat Cancer.

2016-2017

Christine Gao '16

Research Project: Variation of NLS-2 Flanking Sequences in TR?1

Zachary Nimmo '16

Research Project: Employing Unnatural Amino Acids Towards Therapeutic Bioconjugates.

2015-2016

Andrew Halleran '15

Research Project: Global Transcriptomic Analysis of Compensatory Response to Genetic Perturbation of the North Signaling Pathway.

Diya Uthappa '15

Research Project: Exploring the Antibacterial Properties of Polyynes.

2012-2013

Charlotte Platner '12

Research Project: Mass-spectrometry Based Proteomics and Fragmentation Behavior of Lysine Containing Peptides.

2011-2012

Sam Harvey '11

Research Project: Characterization of the two component signal transduction pathway within the gastric pathogen helicobacter pylori.

Brian Rabe '11

Research Project: Determination of the activity-dependent mechanisms initiated by changes in cellular behavior that control neurotransmitter phenotype expression.

2010 - 2011

Robert Frederick Lambert '10

Research Project: Bi(Oft)3-Mediated, One-Pot, Epoxide Rearrangement, Intramolecular Silyl-Modified Sakurai (ISMS) Sequence Toward Dihydropyrans.

Brittany Lewis '10

Research Project: Voltage gated calcium channels and neurotransmitter phenotype specification.

2008-2009

Michael Harper '08

Research Project: The Role of Notch Signaling in Neurotransmitter Phenotype Specification in Xenopus laevis

2007-2008

Andrew Hughes '07

Research Project: The role of calcium signaling in neurotransmitter phenotype determination in Xenopus laevis.

Scholarly Recognition:

Honors, senior honors thesis (see title above)
First-author poster, national meeting of the Society of Developmental Biology

Ian Webb '07

Research Project: The Experimental and Theoretical Gas-Phase Acidities of L-Arginine Analogues.

Scholarly Recognition:

Honors, senior honors thesis (see title above)
Research presentations at undergraduate science symposia
Coauthor, "Gas-phase acidities of the 20 protein amino acids," International Journal of Mass Spectrometry, 267:1-3 (1 November 2007), 54-62.2006-07

2006-2007

Maria Happel '06

Research Project: Specification of Neurotransmitter Phenotypes in Xenopus laevis

Scholarly Recognition:

Highest honors, senior honors thesis (see title above)
Guy Prize recipient, W&M Chemistry Department's highest award for graduating seniors
Presentation: "Investigations of the Effects of Different Collision-Energy Regimes on Derived Thermochemistry from the Extended Kinetic Method." Maria Happel, Mary Disa M. Raulfs, Jennifer Roskowski, Paul G. Wenthold and John C. Poutsma 55th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, (May 2007).
Paper: "Investigations of the Effects of Different Collision-Energy Regimes on Derived Thermochemistry from the Extended Kinetic Method." Maria Happel, Mary Disa M. Raulfs, Jennifer Roskowski, Paul G. Wenthold and John C. Poutsma, to be submitted.

Natasha Golub '06

Research Project: Specification of neurotransmitter phenotypes in early developmental stages of Xenopus laevis

Presentations:

Golub, N.I., Wester, M., Fisher, K.I., Seeley, J., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Beckman Scholars Symposium, Irvine CA (July 2007).
Golub, N.I., Wester, M., Fisher, K.I., Seeley, J., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Morphogenesis and Regenerative Medicine, Charlottesville, VA (May 2007).
Golub, N.I., Fame, R.M., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Society for Developmental Biology Meeting, Ann Arbor, MI (June 2006).
Li, M., Fame, R., Fisher, K., Golub, N., Saha, M. "Specification of the GABAergic and Glutamatergic Phenotype in Xenopus laevis," Morphogenesis and Regenerative Medicine, Charlottesville, VA (May 2005).

2005-2006

Katherine Fisher '05

Research Project: Determination of the Default Vertebrate Neural Phenotype in Early Development

2004-2005

Melissa Sprachman '04

Research Project: The Use of Bismuth Compounds in the Non-toxic Syntheses of Natural Products

Scholarly Presentations:

"Stereoselective Tandem Cylization-Addition Reactions Using Catalytic BiBr3," Southeastern Regional Meeting of the American Chemical Society (SERMACS), November 2004, Research Triangle Park, NC (poster presentation).
"Bismuth Initiated Tandem Cyclization-Addition Reactions for the Synthesis of Cyclic Ethers," Beckman Scholars Symposium, July 2005, Irvine, CA (poster presentation).
"Selective Tandem Cyclization-Addition Reactions Using Catalytic Quantities of BiBr3 and pi-Nucleophiles," 230th National Meeting of the American Chemical Society, August-September 2005, Washington, D.C. (poster presentation).

Lamia Wahba '04

Research Project: Chromosome Mutation 528 in C. elegans

Scholarly Presentations:

"Chromosome mutation 528 in C. elegans: Who, What and When?" Undergraduate Science Research Symposium, College of William and Mary, September 2004, Williamsburg, VA.
"Chromosome segregation defect 528 in C. elegans (and modeling the cell cycle)" Beckman Scholars Symposium, July 2005, Irvine, CA.
"Chromosome segregation defects in Caenorhabditis elegans," Undergraduate Symposium, September 2005, Richmond, VA (poster presentation).
"Modeling the cell cycle in C. elegans, and chromosome segregation defects," Cell Biology meeting, December 2005, San Francisco, CA (poster presentation).

2003-2004

Vijay Dondeti '03

Research Project: Using Microarrays to Study Neural Differentiation and Plasticity in Xenopus laevis

Publications:

V. R. Dondeti, M. A. Wright, and M. S. Saha, "Design of an 8K Xenopus Microarray for Investigating Neural Development," Developmental Biology, 2003, 259(2): 527.
V. R. Dondeti, C. W. Sipe, and M. S. Saha, "A Gene Selection Strategy for Custom Microarray Design," Biotechniques, 2004, 37(5):768-70, 772, 774-6.

Scholarly Presentations:

"A Gene Selection Strategy for Custom Microarray Design: Application to a Xenopus Microarray," Sixth Annual Beckman Scholars Symposium, July 2004, Irvine, CA.
"Molecular Analysis of Early Embryonic Plasticity in CNS," Morphogenesis and Regenerative Medicine Symposium, May 2003, Charlottesville, VA (poster presentation).
"Design of an 8K Xenopus Microarray for Investigating Neural Development," Society for Developmental Biology Meeting, July 2003, Boston, MA (poster presentation).

Megan Dellinger '03

Research Project: Design, Synthesis and Catalysis Application of Metal Network Materials

Publications:

J. R. Cole, M. E. Dellinger, T. J. Johnson, B. A. Reinecke, R. D. Pike, W. T. Pennington, M. Krawiec and A. L. Rheingold, "Caged Phosphite Complexes of Copper(I) Halides," Journal of Chemical Crystallography, 2003, 33, 341-347.
R. D. Pike, B. A. Reinecke, M. E. Dellinger, A. B. Wiles, J. D. Harper, J. R. Cole, K. A. Dendramis, B. D. Borne, J. L. Harris, and W. T. Pennington, "Bicyclic Phosphite Esters from Pentaerythritol and Dipentaerythritol: New Bridging Ligands in Organometallic and Inorganic Chemistry," Organometallics, 2004, 23, 1986-1990.

Scholarly Presentations:

B. D. Borne, J. R. Cole, M. E. Dellinger, K. A. Dendramis, J. D. Harper, and R. D. Pike, "Caged Phosphite Ligands from Pentaerythritol and Dipentaerythritol," 54th Southeastern Regional Meeting of the American Chemical Society, November 2002, Charleston, SC.
R. D. Pike, M. E. Dellinger, B. A. Reinecke, A. B. Wiles, "New Caged Phosphite Metal-Organic Networks," 55th Southeastern Regional Meeting of the American Chemical Society, November 2003, Atlanta, GA.

2001-2002

Edith Bowers '01

Research Project: Development of New Techniques for Studying Protein Structure and Folding

Publications:

Bebout, D. C.; Bush, J. F., II; Crahan, K. K.; Bowers, E. V.; Butcher, R. J. "Sterically Demanding Multidentate Ligand Tris[2-(6-methylpyridyl)methyl]amine Slows Exchange and Enhances Solution State Ligand Proton NMR Coupling to 199Hg(II)" Inorg. Chem 2002, 41, 2529.
Bebout, D. C.; Murphy, G. S.; Garland, M. M.; Bowers, E. V.; Butcher, R. J. "Investigation of the Mercury(II) Coordination Chemistry of Tris[(1-methylimidazol-2-yl)methyl]amine by X-ray Crystallography and NMR," Dalton Trans. 2003, 2578-2584.

Scholarly Presentations:

Bowers, E.V.; Monsess, R. L.; Garland, M. M.; Bebout, D. C.; Butcher, R. J. "Effects of Ligand Symmetry on Hg(II) Coordination" presented at the 220th ACS National Meeting, Washington, D.C., August 21, 2000, CHED 173.
Bowers, E. V.; Monsess, R. L.; Garland, M.M.; Bebout, D. C.; Butcher, R. J. "Effects of Ligand Symmetry on Hg(II) Coordination" presented at the Virginia Section ACS Meeting, Richmond, VA, September 29, 2000.
Bowers, E. V.; Bebout, D. C. "Development of New Techniques for Studying Protein Structure and Folding" Fourth Annual Beckman Scholars Symposium, Newport News, CA, July 2002.
Bowers, E. V.; Bebout, D. C.; Stokes, S. W.; Clements, J. C.; Kastner, M. E.; Butcher, R. J. "Comparison of Hg(II) and Cd(II) coordination with dipodal and tripodal ligand systems" 224th ACS National Meeting, Boston, MA, August 2002, CHED 159.

Christen Raymond '01

Research Project: Variation in the Neuroendicrine Pathway of Reproductive Photoresponsiveness in Rodents

Scholarly Presentations:

Raymond, Christen M.; Kristin A. Schubert, and Paul D. Heideman. Variation in Sensitivity to Steroid Negative Feedback in a Population of White-footed Mice, Peromyscus leucopus. Eighth meeting of the Society for Research on Biological Rhythms, Amelia Island Plantation, Jacksonville, Florida, 22-26 May, 2002 (Poster Presentation).
Raymond, Christen M.; Kristin A. Schubert, and Paul D. Heideman. Variation in the Neuroendocrine Pathway of Reproductive Photoresponsiveness in Rodents. Fourth Annual Beckman Scholar Symposium, Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, Irvine, CA. 25-27 July, 2002. (Poster Presentation)

2000-2001

Annaka Begley Lorincz '00

Research Project: Neural Variation Using Photperiod as a Model

Publications:

Price, Matthew R. Kruse, Julie A. M., Galvez, Eric, Lorincz, Annaka M., Avigdor, Mauricio and Heideman, Paul D. 2005. Failure to Respond to Endogenous or Exogenous Melatonin May Cause Nonphotoresponsiveness in Harlan Sprague Dawley Rats. Journal of Circadian Rhythms 3:12
Lorincz, Annaka M., M. Benjamin Shoemaker, and Paul D. Heideman. "Genetic variation in photoperiodism among naturally photoperiodic rat strains," American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (revised manuscript in review).

Scholarly Presentations:

Verizon Undergraduate Research Symposium, September, 2001.
"Brain Variation Using Photoperiod as a Model," Third Annual Beckman Scholar Symposium, Irvine, CA. (July, 2001).

Ann Mikowski '00

Research Project: Aryl Iodanes: Syntheses and Reactivity

Publications:

Hinkle, R. J., Mikowski, A. M. "Kinetics of Stereoisomeric 2-Methyl-1-butenyl-(aryl)iodonium triflates," Included in a special issue of ARKIVOC 2003, vi, 201-212, published 25 July 2003: http://www.arkat-usa.org/ark/journal/2003/Varvoglis/AV-

Scholarly Presentations:

Mikowski, A. M., Hinkle, R. J., "The Attempted Synthesis of Alkenylbenziodoxole Derivatives," Verizon Undergraduate Science Research Symposium, 15 September 2000; poster 52.
Mikowski, A. M., Hinkle, R. J., "Aryl Iodanes: Syntheses and Reactivity," Third Annual Beckman Scholar Symposium, Irvine, CA. (July 2001).
Mikowski, A. M., Hinkle, R. J. "Fragmentation Reactions of Alkenyl(aryl)iodonium Salts," Verizon Undergraduate Research Symposium at William and Mary, September. 2001. Poster Presentation.
Hinkle, R. J., Mikowski, A. M. "Fragmentation Reactions of Alkenyl(aryl)iodonium Tiflates Salts." Presented at the 223rd American Chemical Society Meeting, Orlando, Fl, April 06-11, 2002. Poster Presentation 332.

1998-1999

Kristina Hoke '98

Research Project: Role of Neurotransmitter Systems in Embryonic Brain Development

Scholarly Presentations:

Undergraduate Research Symposium, College of William and Mary, September, 1999.
First Annual Arnold and Mabel Beckman Scholar Symposium, Irvine, CA (July 22-24, 1999).
National Symposium for the Society of Developmental Biology, June, 1999 (poster presentation). Abstract published in Developmental Biology, Society for Developmental Biology Program/ Abstracts, Academic Press (June, 1999).

Anne McNeil '98

Research Project: Synthesis and Solvolysis of Alkenyl(arl)iodonium Triflates.

Publications:

McNeil, A. J.; Hinkle, R. J.; Rouse, E. A.; Thomas, Q. A.; Thomas, D. B. "Vinyl Carbocations: Solution Studies of Alkenyl(aryl)iodonium Triflate Fragmentations," Journal of Organic Chemistry, 2001, 66, 5556-5565.
Hinkle, R. J., McNeil, A. J., Thomas, Q. A., Andrews, M. N., "Vinyl Cations in Solution: Kinetics and Products of Alkenyl(arl)iodonium Salt Fragmentations," Journal of the American Chemical Society, 1999, 121, 7437-7438.

Scholarly Presentations:

McNeil, A.J., Hinkle, R. J., "Synthesis and Solvolysis of Alkenyl(arl)iodonium Triflates," First Annual Arnold and Mabel Beckman Scholar Symposium, Irvine, CA (July 22-24, 1999).
McNeil, A. J., Thomas, Q. B., Andrews, M. N. (Hinkle, R. J.), Thirteenth National Conference on Undergraduate Research, University of Rochester, Rochester, NY (April 8-10, 1999).
Hinkle, R. J., Aubry, Q. D., McNeil, A.J., National American Chemical Society Meeting, Boston, MA (August 23-27, 1998), poster 240.

Lucia Wille '98

Research Project: The Anaphase-Promoting Complex is Required for C. elegans Meiosis I Anaphase

Publications:

*Davis ES, *Wille L, Chestnut B, Sadler P, Shakes D, and Golden A. (2002) Multiple subunits of the C. elegans Anaphase Promoting Complex are required for chromosome segregation during meiosis I. Genetics 160: 805-813. (*co-first authors)
Sadler, P, Wille L, Young T, Holt G, Johnson N, Letts D, Kaattari I, Thomas J, and Shakes D, "MAT mutants: Metaphase-anaphase transition Defective," Worm Breeder's Gazette 15, no. 4 (1998): 44.
Chase D, Wille L, Ferris D, Golden A, and Shakes D, "Chromosome segregation: A role for APC genes in C. elegans," Worm Breeder's Gazette,15, no. 4, (1998): 45.

Scholarly Presentations:

Wille, L and Shakes, D.C, "The anaphase-promoting complex is required for C. elegans meiosis I anaphase," William and Mary Undergraduate Science Research Symposium. September 1999.
Wille, L and Shakes, D.C, "The anaphase-promoting complex is required for C. elegans meiosis I anaphase," The First Annual Beckman Scholars Symposium, Irvine, CA, July 1999.
Wille, L. and Shakes, D. C., "Mitotic defects in C. elegans emb-27 mutants," William and Mary Undergraduate Science Research Symposium. September 1998.
Wille L, Abdolrasulnia M, and Shakes, D, "The anaphase-promoting complex is required for meiosis I anaphase," International C. elegans Conference. Madison, WI. June 2-7, 1998.